The Pawtucket Brewery hires new bosses, who decide to change the company's mascot. In an attempt to be crowned the new face of Pawtucket Ale, Peter and Brian go head-to-head.
Stewie and Brian compete for the inheritance of a wealthy, older heiress. Meanwhile, Peter and Chris battle for Mr. Herbert's affection.
To the surprise of all the Griffins, Meg makes the U.S. Olympic team as a biathlete and competes in the Winter Olympics.
After Meg saves Stewie from a choking incident, Stewie makes it his personal mission to create a better life for Meg. Meanwhile, Chris is sent to a vocational school.
Lois receives a surprising birthday present from her father, Carter Pewterschmidt, that leads to an unfortunate accident leaving him dependent on Lois and the Griffin's care.
After Brian teases Stewie for being small, Stewie invents a shrinking machine that results in both of them shrinking to a microscopic size.
To Stewie's surprise, he quickly befriends a boy his age, but is devastated when he realizes he isn't invited to his birthday party. Meanwhile, Peter and Lois attend a self-empowerment seminar.
Brian's marriage to Jess is not what he envisioned, especially after her miraculous recovery from cancer. At the suggestion of Peter, Brian lets himself go, causing Jess to make a surprising decision.
Brian meets and quickly falls in love with a woman named Jess, who reveals she has cancer. After she receives devastating news regarding her diagnosis, Brian proposes marriage to her.