The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."
Stan goes to great lengths to compete against his rival, Chuck White, and become the new deacon of their church. Meanwhile, Roger's ""temporary problem,"" which Stan tries to use to his advantage, causes all sorts of problems for Steve, Betsy, the rest of the family, and eventually, Stan.
Francine decides to throw a block party to get in touch with the neighborhood. Stan learns his new neighbors are Iranian and immediately suspects that they are terrorists. To prepare Steve for living near terrorists, Stan makes Steve join a group of scouts, who turn out to be trouble makers. Roger is convinced he possesses hidden alien powers and is determined to find out what they are. MORE -LESS
Stan invites his boss over for dinner, but the Smith family fears getting caught hiding Roger. After a close-call, Roger goes into a coma, making everyone thinking he's dead. After the family disposes of his body, Roger tries to get back home, but he ends up in another risky situation with the CIA.
When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin. MORE -LESS
Hayley comes home from a Green Party rally with her hair dyed green, instigating a fight with Stan. While she's sleeping, Stan cuts her hair (for her own good, of course). After learning of what Stan did, a wigged Hayley defies her father yet again by moving into the van of her new boyfriend. When Stan cuts her off financially, she gets a job as a waitress in a strip club, which pushes Stan right off the edge. Meanwhile, Steve tries to pass Roger off as his disfigured sister in order to cop a feel with a female classmate. MORE -LESS
Stan Smith is mad because after getting his wife a job (or "hobby") as a Real Estate agent, she makes more money than him. In the meantime, his daughter Hayley ran a program that helped the homeless, and Stan's son Steve had an idea to have a Bum Fight program. To get back and to try to gain more money than his wife, Stan takes Steve's idea and starts a Bum Fight Night where he takes bets and treats the homeless like wrestlers. But with the homeless petition, Stan has to end up fighting like a homeless man himself. MORE -LESS
Stan Smith uses his CIA skills to help 13-year-old son Steve win class president and the heart of the hottest girl in class, Lisa Silver. But when being class president makes Steve mad with power, Stan must jump in to save the day. Meanwhile, Roger, the alien Stan saved from Area 51, helps 18-year-old Hayley with her school paper. In return, she hooks him up with boatloads of junk food to curb his sweet tooth. Unfortunately, some Chocodiles send him over the edge and a sugar crash prohibits him from finishing one of her papers, forcing Hayley to pick up the pieces. And Klaus, the goldfish with the brain of a German guy, pines after mother Francine. Unfortunately for Klaus, the closest he'll ever get to a date with her is the spin cycle with her sports bra. MORE -LESS