Fry discovers the ability to download any celebrity onto a blank robot, and chooses to download Lucy Liu, with whom he falls madly in love. Repulsed by this disgusting display of human/robot love, Leela, Bender, and Zoidberg set out to shut down Nappster.com and put an end to illegal celebrity downloads forever.
While creating a team of mutants to play the Harlem Globetrotters, the Professor accidentally causes a disruption in time that threatens the existence of the universe. Meanwhile, Fry tries to win an unreceptive Leela's heart.
When Bender is paralyzed in a tragic can opener accident, he discovers his musical washboard skills and goes on tour as a member of Beck's folk-rock band, acting as a voice for broken robots everywhere. Fry, Leela, Amy, and Zoidberg tag along in Fry's antique 1960s VW Van.
Accused of robbing a bank, Fry and Bender plead insanity and are both sent to a robot insane asylum. While Bender and his buddy Roberto plan an escape, Fry is brainwashed into thinking that he is a robot.
Leela meets up with her former orphanarium playmate Adlai Atkins, now a plastic surgeon, who offers to grant Leela surgery that will give her two eyes. Meanwhile, Bender adopts twelve orphans in order to collect $1200 in government stipends.
After a string of bad luck, Fry ventures into the decaying ruins of Old New York to regain his lucky seven-leaf clover from his childhood, only to find that his brother Yancy Fry had stolen not only the clover, but Fry's identity as well. Fry sets out to exhume his brother's body, but discovers the startling truth about Yancy instead.
A sober Bender crashes a dark matter tanker on Pluto, threatening the penguin reserve nearby. Leela helps out in the clean-up, but when the penguins begin mating out of control, drastic action must be taken to thin the herd.
Dr. Zoidberg reunites with his uncle, silent hologram star Harold Zoid, and the two of them set out to make a movie together. They cast the temperamental Calculon in the lead role, who demands an Oscar for his performance, but the movie doesn't go over well with audiences.
Earth is invaded by super-intelligent flying brains, who sap the Earth's populace of their intelligence. Leela is taken to Nibbler's home planet Eternia, where the Nibblonians explain that only one human is immune to the brains' powers - Fry.
Bender's urge to bend prompts Professor Farnsworth to send him on a rehabilitation visit to a steel factory, where he falls in love with a shapely fem-bot named Angleyne. But Bender's old rival Flexo and the intrusion of the Robot Mafia threaten to throw a wrench into the proceedings.
A double-date for Kif, Amy, Zapp, and Leela ends in disaster when their orbiting restaurant crashes on planet Amazonia. The hulking female inhabitants of the planet take their male captives to the omniscient Femputer, who orders Fry, Zapp, and Kif to death by "snu-snu".
When Fry becomes infested with parasitic worms that make him stronger and smarter, he finally finds the perfect way to profess his feelings to Leela. Meanwhile, the rest of the crew goes on a journey into Fry's body to eradicate the worms.
Fry, Leela, and Bender all lose their jobs at Planet Express, and they endeavor to return to their old jobs. Due to a mix-up of their career chips, Fry becomes a career counselor at Applied Cryogenics, where he meets up with a familiar defrostee - his girlfriend from the 20th century, Michelle.
Bender and Fry volunteer for military duty to enjoy the benefits of the soldiers' discount. When war breaks out later that same day, Leela too decides to join the all-male ranks, under the guise of Lee Lemon, and creates quite a stir for her leader, Zapp Brannigan.
At his late Uncle Vladimir's estate, Bender is run over by a vicious Werecar, inheriting the curse. The only way to stop Bender's fatal transformations is to seek out and destroy the original Werecar - the deadly Project Satan.