When Amy’s parents and Sheldon’s family arrive for the wedding, everybody is focused on making sure all goes according to plan – everyone except the bride and groom.
When Sheldon learns that his mother won’t attend his wedding unless he invites his brother, Georgie, he and Leonard travel to Texas to end a family feud. Also, the Wolowitz kids inadvertently infects Amy, Bernadette, Wolowitz and Koothrappali with pinkeye.
Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies.
Sheldon’s comic book store experiences changes when writer Neil Gaiman puts Stuart’s store on the map. Also, Koothrappali takes credit for Penny’s astronomical discovery, and friendships are threatened.
Sheldon takes the guys to a cabin in the middle of nowhere to meet a reclusive scientist; Penny and Bernadette improvise Amy's bachelorette party.
When Leonard learns Sheldon is the president of the tenants association, he decides to run against him. Also, Bernadette encourages Wolowitz and Koothrappali to find the owner of a drone after they find it in the backyard.
Penny gets the opportunity to host Bill Gates at work when his company wants to partner with her pharmaceutical company. Also, Leonard, Koothrappali and Wolowitz do everything in their power to meet him, while Sheldon thinks he is the victim of an April Fools prank.
Leonard jumps through hoops to help secure the perfect wedding venue for Sheldon and Amy. Also, Bernadette and Wolowitz have a hard time deciding who should stay at home with the kids and who should go back to work.
When Bernadette won't go into labor, all her friends try different tactics to get things started. Also, Wolowitz confronts Bernadette after Amy accidentally reveals she's already chosen their son's name.
When Sheldon petitions Wil Wheaton to appear on the new Professor Proton show, Wil offers a role to Amy instead. Also, Penny gets angry when she thinks the female protagonist in Leonard's novel is based on her.
Koothrappali finds himself in the middle of domestic drama when he learns the woman he's dating, Nell, has a very upset husband, Oliver. Also, when Sheldon rents his old room back for a quiet place to work, he drives Leonard crazy by being a model tenant.
When Sheldon kicks Amy out to work solo, she and Leonard bond during a series of science experiments. Bert the geologist replaces Howard in the band Footprints on the Moon. Sheldon finds Penny a surprising source of scientific inspiration.
To discover who would be most qualified to be best man and maid of honor at their wedding, Sheldon and Amy subject their friends to a series of secret experiments. Penny reveals her true feelings about Amy.
Sheldon and Howard plan birthday celebrations for Amy and Halley, respectively. Leonard receives a Christmas letter from his brother that causes him to spiral out about his own lack of accomplishments.
Sheldon and Amy try to eliminate stress from wedding planning by applying math to the process. Also, Koothrappali “breaks up” with Wolowitz after realizing his best friend is actually hurting his confidence.
Sheldon tries to teach the guys a lesson after they cut him out of a potentially valuable Bitcoin investment. Also, a seven-year-old video reveals a secret about Leonard and Penny’s relationship.
Leonard and Howard are furious after they learn Sheldon went to work with the military behind their backs. While Bernadette is on bed rest, she asks Raj to do some digging when she suspects Ruchi is trying to steal her job.
Sheldon and Bert collaborate on a research project, despite Sheldon’s embarrassment. Also, Penny and Bernadette coach Koothrappali on how to navigate his relationship with Ruchi.
Sheldon goes head-to-head with Wil Wheaton for the role of the new Professor Proton. Also, Penny steps in to take care of Halley when Bernadette and Wolowitz both wind up on bed rest.
Sheldon and Koothrappali confide in Bernadette when they can't handle Amy and Wolowitz working together. Also, Penny and Leonard learn new tactics for how to deal with Sheldon from an unlikely source.
Wolowitz and Sheldon bond when they drive to the desert to shoot off a model rocket. Also, when Leonard's mom finds a new best friend in Penny, it rubs Leonard the wrong way.
As Sheldon stresses about picking a wedding date, Amy tries to convince him he has a more laid-back side. Also, Koothrappali and Stuart compete to win the heart of Bernadette's new co-worker, Ruchi.
Leonard angers the university – and the entire physics community – after he gives an embarrassing interview. Also, Amy and Bernadette bond over having to hide their success from Sheldon and Howard.
In the eleventh season opener, Amy gives Sheldon an answer to his proposal while Howard and Bernadette struggle with some unexpected news.
