Teresa, James and Guero travel to Bolivia in search of a new supplier: the mysterious and dangerous narco-cult leader El Santo.
Teresa's loyalties are tested when she is asked to assassinate a DEA mole.
While trying to destroy Epifanio's drug smuggling tunnels, Teresa and James come face-to-face with a group of American border vigilantes.
Teresa and crew rig a high-stakes narco horse race, but old enemies—and old flames—threaten to tear everything apart.
Teresa brokers a deal with an eccentric smuggler; Camila struggles to rebuild her empire; Epifanio takes on a new partner he may not be able to control.