As rival alley-cat crews face off for control of the streets of Little Italy, a young feline rises to the top of the pack; three owls gather for Christmas celebrations.
Rat teens Mike and Phil plot to exploit a human baby for profit, but things take a dark turn as the stakes increase; two bees fight over the love of a tulip.
Inside the headquarters of an evil conglomerate, the unscrupulous Dr. Labcoat prepares to roll out a mysterious cure for the virus plaguing New York.
With New York quarantined and in disarray, Mike and Phil prepare for their mother's remarriage; Mike tries to impress a female wedding guest; Phil plots to stop his mother's wedding.
When an exterminator puts a roach town in crisis, the survivors band together to travel to the world outside their wall and guarantee the survival of their species. Stuck together by a piece of litter, a group of seagulls struggles to live as one.
A teenage pigeon's jealousy over his angelic little brother leads him on a wacky spirit quest that teaches him about courage and responsibility; two foxes rap about their tough life on the city streets.
Laboratory rats Mike and Phil enter a love triangle with an imaginary friend; two fleas ponder life while stuck on a monkey's back; an algae questions its existence.