To Stewie's surprise, he quickly befriends a boy his age, but is devastated when he realizes he isn't invited to his birthday party. Meanwhile, Peter and Lois attend a self-empowerment seminar.
Brian's marriage to Jess is not what he envisioned, especially after her miraculous recovery from cancer. At the suggestion of Peter, Brian lets himself go, causing Jess to make a surprising decision.
Brian meets and quickly falls in love with a woman named Jess, who reveals she has cancer. After she receives devastating news regarding her diagnosis, Brian proposes marriage to her.